In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2302-25-2 as follows. 2302-25-2
To a solution of 4-bromo-7H-imidazole (lg, 6.80 mmol) in DMF (20 ml) was added NaH (0.272 g, 6.80 mmol) at 0 C. The mixture was stirred for 10 minutes, tert-butyl (3- bromopropyl)carbamate (1.62 g, 6.80 mmol) was added. The solution was stirred at room temperature for 2 hours and then heated at 50C for 1 hour. The mixture was quenched with water (50 ml) and extracted with EtOAc (3×20 ml). The organic layer was washed with water (30mL), brine (30mL) and dried over Na2SC”4. The solvent was removed under vacuum. The residue was purified by column chromatography on silica gel (Redi 40g gold column), and eluted with EtOAc/Hexane (0-100%, 6cv; 100%, lOcv) to give the title compound. LC-MS [M + H]+: m/z 304.19. 1HNMR (500 MHz, CDC13) delta 7.40 (s, 1 H); 6.94 (s, 1 H); 4.67 (s, 1 H); 3.98 (t, J = 7.0 Hz, 2 H); 3.17 (d, J = 7.5 Hz, 2 H); 1.98 (p, J = 6.8 Hz, 2 H); 1.47 (s, 9 H).
According to the analysis of related databases, 2302-25-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; LIU, Weiguo; DING, Fa-Xiang; SUN, Wanying; ZANG, Yi; PAN, Weidong; OGAWA, Anthony; BROCKUNIER, Linda; HUANG, Xianhai; WANG, Hongwu; MAL, Rudrajit; BIFTU, Tesfaye; PARK, Min; GUO, Yan; JIANG, Jinlong; CHEN, Helen; PLUMMER, Christopher, W.; (258 pag.)WO2017/106064; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem