Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows., 641571-11-1
To a solution of 2- (5-ethoxy-6-oxo-1 6-dihydropyridin-3-yl) -4 6-dimethylpyrimidine-5-carboxylic acid (150 mg 0.519 mmol) 3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (125 mg 0.519 mmol) and Et3N (79 mg 0.778 mmol) in 1 4-dioxane (5 mL) stirred under N2at 20 was added DPPA (171 mg 0.622 mmol) in one charge. The reaction mixture was heated to 80 for 1 hr. Then the solution was concentrated. The residue was purified by preparative HPLC (Instrument DC/Column ASB C18 150*25mm/Mobile phase A Water+0.1HCl/Mobile phase BMeCN /Flowrate 25 mL/min /Gradient Profile Description 15-55 (B) ) to yield a off white solid of 1- (2- (5-ethoxy-6-oxo-1 6-dihydropyridin-3-yl) -4 6-dimethylpyrimidin-5-yl) -3- (3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl) urea dihydrochloride (11.53 mg 3.67) . TLC (DCM/MeOH 51 Rf 0.4) 1HNMR(400 MHz CD3OD) delta9.44-9.40 (m 1H) 8.27-8.23 (m 1H) 8.20 (s 1H) 7.92 (s 2H) 7.84 (s 1H) 7.69 (s 1H) 4.17 (d J 6.8 Hz 2H) 2.57 (s 6H) 2.44 (s 3H) 1.48 (t J 6.9 Hz 3H) ES-LCMS m/z 528.2 (M+H)
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem