In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41716-18-1 as follows. 41716-18-1
A mixture of (+/-)-ferf-butyl ((c/s)-3-aminocyclohexyl)carbamate (5 g, 23.3 mmol) and DMAP (7.1 g, 58.3 mmol) in CH2CI2 (100 mL) was stirred at ambient temperature, then 1 -methyl-1 h-imidazole-4-carboxylic acid (2.9 g, 23.3 mmol) was added. After stirring for 10 minutes at room temperature, EDC (6.7 g, 35 mmol) was added. The mixture stirred for 18h at room temperature. The reaction mixture was washed with citric acid (5percent aq.), the organic layer was removed, dried (MgS04), the solids removed by filtration, and the solvent of the filtrate removed under reduced pressure to give (+/-)-f-butyl ((c/’s)-3-(1 -methyl-1 – -imidazole-4- carboxamido)cyclohexyl)carbamate. LC-MS ES+ m/z = 323.5; Rt: 0.75 min, method A.
According to the analysis of related databases, 41716-18-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; GUILLEMONT, Jerome, Emile, Georges; MC GOWAN, David, Craig; EMBRECHTS, Werner, Constant, Johan; COOYMANS, Ludwig, Paul; MICHAUT, Antoine, Benjamin; (162 pag.)WO2016/20526; (2016); A1;,
Imidazole – Wikipedia,
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