Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2034-23-3, name is 5-Chloro-1H-benzo[d]imidazol-2(3H)-one, A new synthetic method of this compound is introduced below., 2034-23-3
Preparation of 6-chloro-l -( 3-chloropropyl)-lH-benzo[|imidazol-2(3H)-one; [0235] Sodium hydride (60% dispersion) (521.8 mg, 13.04 mmol, 1.1 equiv) was added to a solution of 5-chloro-lH-benzo[i ]imidazol-2(3H)-one (2 g, 11.86 mmol, 1 equiv) in N,N- dimethylformamide (50 ml), stirred at ambient temperature under an atmosphere of nitrogen. After 75 minutes a solution of di-tert-butyl dicarbonate (2.59 g, 11.86 mmol, 1 equiv) in NN- dimethylformamide (10ml) was added drop-wise and the mixture stirred for 16 h. The solvent was removed in vacuo and the residue was diluted with sat. ammonium chloride solution. The mixture was extracted with ethyl acetate, the organic layer dried over MgS04, filtered and concentrated in vacuo. The resulting residue was chromatographed using the Biotage flash chromatography system (SNAP 50 g cartridge, Rf = 0.3, gradient - 5 %-30% ethyl acetate in hexanes) to afford the teri-butyl 5-chloro-2-oxo-2,3-dihydro-lH-benzo[i ]imidazole-l-carboxylate as a cream powder (1.41 g, 45%); 'ffNMR (400 MHz, DMSO-i/6): delta 1.57 (s, 9H); 7.01 (d, 1H, J= 2 Hz); 7.09 (dd, 1H, J = 2 Hz); 7.61 (d, lH, J= 9.2 Hz); 11.40 (s, 1H); MS for Ci2H13ClN203 m/z 268.94 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ALTOS THERAPEUTICS, LLC; LUEHR, Gary, W.; SUNDARAM, Arathi; JAISHANKAR, Priyadarshini; PAYNE, Philip, W.; DRUZGALA, Pascal; WO2011/160084; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem