288-32-4, A common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
200.0 ml (1.84 mol) of N,N-dimethylsulfamoyl chloride,147.0 g (2.16 mol) of imidazole and 280 ml of triethylamine were added to 2.5 L of anhydrous diethyl ether with stirring.Stir at room temperature for 16 h. After the reaction is completed, the reaction solution is filtered.The filter cake was washed with 1.5 L of diethyl ether.The filtrate was combined and the filtrate was dried over anhydrous Na Residues, distillation residues to obtain products:305.1g.(0.4 mmHg), placed to form a colorless crystal.Yield: 94.75%
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chenxin Pharmaceutical Co., Ltd.; Wang Qianying; Bie Fenxia; Gong Ruo; Li Zhongjing; Jiang Ruiling; (7 pag.)CN109608400; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem