288-32-4, Name is 1H-Imidazole, 288-32-4, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
In a 50 mL round-bottomed flask, imidazole (1 mmol), phenylboronicacid (1.2 mmol), K2CO3 (1.5 mmol), nanocatalyst (15mol% with respect to imidazole substrate) were added andstirred in MeOH-H2O (1:1) under air at r.t. for the requiredtime, monitoring by TLC. After completion, the mixture wasdiluted with H2O and the product was extracted with EtOAc(3¡Á). The combined extracts were washed with brine (3¡Á) anddried over Na2SO4. The product was purified using columnchromatography (60-120 mesh silica gel, eluting with EtOAc-hexane). The product was isolated as white solid. 1H NMR (400MHz, CDCl3): delta = 7.87 (s, 1 H), 7.50-7.47 (m, 2 H), 7.40-7.35 (m,3 H), 2.28 (m, 1 H), 7.21 (s, 1 H) ppm. 13C NMR (100 MHz,CDCl3): delta = 137.4, 135.6, 130.3, 129.9, 127.6, 121.6, 118.3 ppm.
Statistics shows that 1H-Imidazole is playing an increasingly important role. we look forward to future research findings about 288-32-4.
Reference:
Article; Borah, Raju Kumar; Raul, Prasanta Kumar; Mahanta, Abhijit; Shchukarev, Andrey; Mikkola, Jyri-Pekka; Thakur, Ashim Jyoti; Synlett; vol. 28; 10; (2017); p. 1177 – 1182;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem