1615-14-1, Name is 2-(1H-Imidazol-1-yl)ethanol, 1615-14-1, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
General procedure: The following examples were prepared using general procedure described below: A solution of corresponding alcohol (3 equiv) in THF (3 mE) was stirred in an ice-water bath under an atmosphere of Argon. Potassium tert-butoxide (1.0 M, 3 equiv) was added in a single portion and the mixture was stirred at 00 C. for 30 minutes, and then 2-fluoro-5-(4- ((4-(4-(oxetan-3-yl)piperazin-1 -yl)phenyl)amino)-1 ,3,5-tri- azin-2-yl)benzonitrile was added (1 equiv). The mixture was stirred for 2 hr at it Afier the mixture cooled to room temperature, water was added, and mixture evaporated under reduced pressure. Solids were purified via preparative HPEC (5-65% acetonitrile in water, 0.1% trifluoroacetic acid buffer)to yield the final product.
Statistics shows that 2-(1H-Imidazol-1-yl)ethanol is playing an increasingly important role. we look forward to future research findings about 1615-14-1.
Reference:
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
Imidazole – Wikipedia,
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