As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84946-20-3 name is 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 84946-20-3
Example 4; A/-[3-(1-{3-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-propyl}-piperidin-4-yl)-phenyl]-acetamide; 2-Chloro-1-(4-fluoro-benzyl)-1H-benzoimidazole (58 mg, 0.22 mmol) and A/-{3-[1-(3-Amino-propyl)-piperidin-4-yl]-phenyl}-acetamide (Example 1 Step 2, 90 mg, 0.33mmol) were mixed in ethanol (1 ml) and heated in the micro wave at 150 C for 2h.The reaction was extracted with dichloromethane and Na2CO3(aq) and the combinedorganic phases was dried over Na2SO4, filtered, and evaporated giving the crudeproduct which was purified by chromatography (silica,dichloromethane/methanol/ammoniac, 9:1:1%) giving the title compound Example 4.1H-NMR (300 MHz, CDCI3); 8 7.5.1 (d, 1H), 7.38 (s, 1H), 7.10-7.31 (m, 6H), 6.92-7.02(m, 4H), 6.79 (d, 1H), 6.61 (br s, 1H), 5.17 (s, 2H), 3.71 (t, 2H), 3.14 (d, 2H), 2.62 (t,2H), 2.48-2.61 (m, 1H), 2.21 (s, 3H) 2.06-2.15 (m, 2H), 1.91-2.00 (m, 2H), 1.65-1.86(m, 4H).LCMS: Rt 3.48 min, m/z 499.6 [M+].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.
Reference:
Patent; 7TM PHARMA A/S; WO2006/10446; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem