As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1546-79-8 name is 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 1546-79-8
A solution of 2-benzo [1, 3] dioxol-5-yl-l- (6-bromo-pyridin-2-yl)-ethanone (0. 359 mmol) in anhydrous THF (5 mL) was added to a slurry of sodium hydride (0. 725 mmol) in anhydrous THF (5 mL) at RT. After 5 minutes, N- TRIFLUOROACETYLIMIDAZOLE (0. 395 mmol) was added. After an additional 30 minutes at room temperature, hydrazine (1. 5 mL) was added. After another 30 minutes, glacial acetic acid (10 mL) was added and the reaction warmed to 100 C for 1 hour. The reaction was then concentrated in vacuo and purified via reverse phase HPLC (acetonitrile-water gradient) to give a solid identified as 2- (4-BENZO [1, 3] dioxol-5-yl-5- TRIFLUOROMETHYL-LH-PYRAZOL-3-YL)-6-BROMO-PYRIDINE : MS (ESP+) 411. 9 (M+1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; BIOGEN IDEC MA INC.; WO2004/72033; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem