In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1003-21-0 as follows. 1003-21-0
A solution of compound 101a ((1.6 g, 10 mmol), compound sodium 4-(tert-butyl)benzenesulfinate (3.3 g, 15 mmol) and Cul (1.9 g, 10 mmol) in DMF (20 mL) was heated at 110 C for 18 hours under N2. The reaction was then cooled down and filtered. H2O (100 mL) was added to the filtrate and the mixture was extracted with EtOAc (100 mLx 3). The combined organic layers were dried with anhydrous Na2SO4 and concentrated with a Rotavapor. The residue was purified by silica gel chromatography (Petroleum Ether/EtOAc = 10/1 to 2/1) to give the chemical 102a (1.18 g, 42% yield). 1H NMR (CDC13, 400MHz): delta (ppm) 7.83 (d, 2H, J = 8.4 Hz), 7.72 (s, 1H), 7.53 (d, 2H, J = 8.4 Hz), 7.48 (s, 1H), 3.71 (s, 3H), 1.31 (s, 9H). m/z 279 (M+H)+
According to the analysis of related databases, 1003-21-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ST. JUDE CHILDREN’S RESEARCH HOSPITAL; CHEN, Taosheng; LIN, Wenwei; WANG, Yueming; (239 pag.)WO2017/165139; (2017); A1;,
Imidazole – Wikipedia,
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