Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., 288-32-4
c: 1-Benzyl-2-chloromethyl-imidazole, oxalate A solution of imidazole (13.6 g, 200 mmol) in 33% aqueous sodium hydroxide is heated to 100 C. for 10 min, the water is removed in vacuo and the crystalline sodium salt is dried at 0.1 mBar and 160 C. for 40 min. The salt is dissolved in 100 ml acetonitrile and is added benzylbromide 23.8 ml, 200 mmol). After stirring at 50 C. for 30 min, the mixture is concentrated in vacuo and the formed NaBr is removed by trituration in ethylacetate and filtration. On concentration in vacuo 1-benzyl-imidazole is obtained as an orange oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NeuroSearch A/S; US5296493; (1994); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem