As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23785-21-9 name is Ethyl 1H-imidazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 23785-21-9
The starting material for the above process was obtained as follows: A suspension of ethyl imidazole-4-carboxylate (1.4 g), triethylamine (1.2 g) and chloroform (20 ml) was stirred at room temperature while trityl chloride (3.06 g) was added, and the mixture was stirred at room temperature for 1 h. The resulting solution was washed with water, dried and evaporated to dryness under reduced pressure, and the residue was crystallized from a mixture of ethyl acetate and cyclohexane, to give ethyl 1-tritylimidazole-4-carboxylate, mp 163-164.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1H-imidazole-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Imperial Chemical Industries plc; US4935437; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem