Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 641571-11-1
To a solution of 3 (500 mg, 2.1 mmol) and 48 (489 mg, 2.1 mmol) in CH2CI2 (10mL) was added pyridine (242 mg, 3.1 mmol), dropwise. The reaction was stirred atroom temperature overnight. Water was added and the mixture was extracted with CH2CI2 twice. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel column chromatography to give 49 (180 mg, 20%) as a slightly yellow solid. LCMS (m/z: m+1): 441 .1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-11-1, its application will become more common.
Reference:
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem