144689-93-0, The chemical industry reduces the impact on the environment during synthesis 144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, I believe this compound will play a more active role in future production and life.
400 ml of acetone was added to a 1 L glass reaction flask, and 111. 4 g of N-(triphenylmethyl)-5-(4′-bromomethylbiphenyl-2-yl)tetrazole, 48.0 of ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazol-5-carboxylate was added with stirring, 55.2 g of potassium carbonate, 6.4 g of tetrabutylammonium bromide, heated to 50-60 C, After the incubation reaction for 20 hours, the temperature was lowered to 20-30 C, 200 ml of water was added, stirred for 30 minutes, and filtered, and the filter cake was successively rinsed with 200 ml of water and 200 ml of acetone. The filter cake was air-dried at 40-50 C for 12 hours to give a white solid, 130.0 g ( Intermediate 1), yield: 90.7%, HPLC: 98.6%.
The chemical industry reduces the impact on the environment during synthesis Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Jiashi (Hunan) Pharmaceutical Technology Co., Ltd.; Dai Yongzhi; Liu Hu; Zhu Laifa; Cai Jian; (8 pag.)CN108341804; (2018); A;,
Imidazole – Wikipedia,
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