934-22-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 934-22-5, name is 6-Aminobenzimidazole, A new synthetic method of this compound is introduced below.
Compound 216; 1 -(1 H-Benzoimidazol-5-yl)-4-benzylimino-5-(4-bromo-phenyl)- imidazolidin-2-one; 1 H-Benzoimidazol-5-ylamine (1 mmol) and 4-Bromobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2ml of a solution of KOCN (KSCN) (2mmol) and Pyridinehydrochloride (2mmol) in MeOH is added was added. Finally 3- Benzylisocyanide (1 mmol) is added. The reaction was stirred at room temperature for 48h. After evaporation of the solvent the residue was purified with chromatographic methods. Yield: 0.230 g (50 %); mp: 244C, 1H-NMR (500 MHz, DMSO-D6): 4.46 (t, 3J=5.1 Hz, 2 H, CH2), 6.18 (s, 1 H, CH-N), 7.17 (m, 8 H, Ar), 7.39 (d, 3J=8.7 Hz, 1 H, Benzimid), 7.48 (dd, 3J=6.6 Hz, 4J=1.9 Hz, 2 H, Ar), 7.67 (s, br., 1 H, NH), 8.08 (s, 1 H, Benzimid), 8.67 (t, 1 H, Ar), 12.36 (s, br., 1 H, NH). . MS m/z 460.3 (M+H)+, HPLC (254 nm): rt 2.86 min (100 %)molecular weight (g/mol): 460.34 IC50 hQC (nM): 22
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PROBIODRUG AG; WO2008/55947; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem