4331-29-7, Adding some certain compound to certain chemical reactions, such as: 4331-29-7, name is 1H-Benzo[d]imidazol-7-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4331-29-7.
[00153] IC491791: 2-[l-(4-Amino-benzoimidazol-l-yl)-ethyl]-3-phenyl-3H- thieno[3,2-d]pyrimidin-4-one.; To a solution of 2-(l-Amino-ethyl)-3-phenyl-3H- thieno[3,2-d]pyrimidin-4-one (47 mg, 0.162 mmol) in DMF was added adenine (26 mg, 0.194), followed by the addition of potassium carbonate (22 mg, 0.162 mmol). The resulting mixture was then heated to 125¡ãC in an oil bath for 5 min. The reaction mixture was then cooled to room temperature, then treated with H2O (10 mL) to afford a precipitate. The precipitate was collected and dried in a vacuum oven to afford the crude product. Purification by HPLC (C- 18 Luna column 250 x 21.20 mm, 10-20percent CH3CN/H20 containing 0.05percent CF3CO2H) product was obtained as a fluffy white solid after lyophilizing: 1H NMR (400 MHz, DMSO-d6) delta 8.37 (s, IH), 8.25 (d, / = 5.2 Hz, IH), 8.16 (s, IH), 7.67 (d, / = 8.0 Hz, IH), 7.58 (m, IH), 7.44 (m, 2H), 7.36 (m, IH), 7.17 (d, / = 8.0 Hz, IH), 5.49 (q, / = 6.8 Hz, IH), 1.75 (d, J = 6.4 Hz, 3H). LC/MS (AP-ESI, CH3CO2H 0.05percent) m/z 390 (MH+).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4331-29-7.
Reference:
Patent; ELI LILLY & CO.; WO2008/64018; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem