54624-57-6, A common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Tri-tert-butylphosphine (4.4 mL of 1.0 M in toluene, 1.48 g, 0.05 mmol), palladium acetate (0.4 g, 1.83 mmol) and sodium tert-butoxide (22.8 g, 238 mmol)A solution of 2-bromo-1H-benzimidazole (36.0 g, 183 mmol) and p-methoxybromobenzene (35.0 g, 187 mmol) in degassed toluene (1 L) was added and the mixture was heated under reflux 2 hour.The reaction mixture was cooled to room temperature, diluted with toluene and filtered over EtOAc.The filtrate was diluted with water and extracted with toluene and the organic phases were combined and evaporated in vacuo.The residue was filtered through silica gel and recrystallized.Compound a (44.2 g, yield 80percent) was obtained.
The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Liu Xiqing; Cai Hui; (35 pag.)CN108218787; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem