39021-62-0, A common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2-(3 ,4-dimethoxyphenyl)-3 -i sopropyl -5 -(piperidin-4-yl)- 1 H-indole, HC1 (25 mg, 0.060 mmol) in DCM (0.5 mL) was neutralized by adding triethylamine drop wise (checked by pH paper). The solution was added to a vial containing i-methyliH-imidazole-5-carbaldehyde (9.95 mg, 0.090 mmol), acetic acid (0.01 ml, 0.175 mmol) at room temperature. The mixture was stirred at room temperature for 16 h. Sodium triacetoxyborohydride (19.15 mg, 0.090 mmol) was added to the reaction mixture and the mixture was stirred for another 6 h at room temperature. The reaction mixture was purified by reverse phase prep LCMS to provide 2-(3,4-dimethoxyphenyl)-3-isopropyl-5-(1 -((1 -methyl- 1H-imidazol-5-yl)methyl)piperidin-4-yl)- 1H-indole (1.27 mg, 4.34% yield,97.2% purity) as a pale solid. LC retention time = 1.734 mm [E]. MS (E) m/z: 473.2 (M+H).
The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DYCKMAN, Alaric J.; DODD, Dharmpal S.; MUSSARI, Christopher P.; HAQUE, Tasir S.; POSS, Michael A.; LOMBARDO, Louis J.; MACOR, John E.; PASUNOORI, Laxman; KUMAR, Sreekantha Ratna; (296 pag.)WO2018/26620; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem