54624-57-6,Some common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) In a 250mL three-necked flask, purged with nitrogen, 0.02mol raw material 2-bromo-1H-benzimidazole, 0.03mol iodobenzene, 0.04mol sodium hydride,0.004mol cuprous iodide and 0.01mol o-phenanthroline dissolved in 100ml 1,3-dimethyl-2-imidazolidinone, the reaction was stirred for 20-30h,After the reaction was completed, water was added and the mixture was extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate,A mixture of petroleum ether and ethyl acetate was used as a eluent shower, the volume ratio of petroleum ether to ethyl acetate in the eluent was 1: 100,Purification by column chromatography gave Intermediate M1; HPLC purity 99.5%, yield 75.8%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromobenzimidazole, its application will become more common.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Zhang Zhaochao; Li Chong; (51 pag.)CN107417668; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem