The chemical industry reduces the impact on the environment during synthesis 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life. 641571-11-1
0 ~ 5 ,will3- (4-methyl-1H-1-imidazolyl) -5-trifluoromethylaniline(24.1 g, 0.1 mol),Di-tert-butyl dicarbonate (21.8 g, 0.1 mol)And 200 mL of dichloromethane were added to a three-necked reaction flask,Triethylamine (28.5 g, 0.15 mol) was added dropwise with stirring,After that,Heating up to 25 ~ 35 ,Reaction for 12 hours,TLC detection,To the raw material reaction completely.The solvent was removed under reduced pressure,The resulting residue was recrystallized from ethyl acetate to give a white solidN- [3- (4-methyl-1H-1-imidazolyl) -5-trifluoromethylbenzene] tert-butoxycarbonylamine (III)(Tert-butoxycarbonyl protected compound of formula II), 29.5 g,Yield 86.5%.
The chemical industry reduces the impact on the environment during synthesis 641571-11-1. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Suzhou Lixin Pharmaceutical Co., Ltd.; Xu Xuenong; Bao Zhijian; Su Jian; Xue Jia; Gu Xinyu; Huang Dongliang; Chen Wei; Wang Zhe; (6 pag.)CN107188887; (2017); A;,
Imidazole – Wikipedia,
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