46006-36-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
(3-Methylbenzoimidazol-4-yl)-(l-methyl-lH-spiro[chromeno[4,3- c]pyrazole-4,4′-piperidine]-l’-yl)methanone [00562] Step 1: (lH-Benzo[d]imidazol-4-yl)(l-methyl-lH-spiro[chromeno[4,3- c]pyrazole-4,4′-piperidine]-l’-yl)methanone To a solution of l-methylspiro[chromeno[4,3-c]pyrazole-4,4′-piperidine] (211 mg, 0.830 mmol), lH-benzimidazole-4-carboxylic acid (134 mg, 0.830 mmol) and triethylamine (346 mu, 2.50 mmol) in dichloromethane (2 mL) was added HATU (314 mg, 0.830 mmol) in one portion and the mixture was stirred for 12 hours. The reaction mixture was treated with 1M NaOH (1 mL) for 10 minutes. Dichloromethane (5 mL) was added. The two layers were separated and the aqueous layer was extracted with dichloromethane (2 x 5 mL). The organic layers were combined, washed with brine, dried over MgSC^, filtered and evaporated to yield a residue that was purified on silica using a gradient of 0.5-30% MeOH in dichloromethane to yield (lH-benzo[d]imidazol-4-yl)(l -methyl- lH-spiro[chromeno[4,3-c]pyrazole-4,4′- piperidine]-l’-yl)methanone. ESI-MS m/z calc. 399.5, found 400.5 (M+l)+. Retention time: 1.12 minutes (4 min run).
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Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; KALLEL, Edward, Adam; MILLER, Mark, Thomas; PONTILLO, Joseph; ANDERSON, Corey; NUMA, Mehdi; FRIEMAN, Bryan, A.; BEAR, Brian, Richard; ARUMUGAM, Vijayalaksmi; HILGRAF, Nicole; MCCARTNEY, Jason; GROOTENHUIS, Peter, Diederik Jan; JOHNSON, James, Philip; WO2011/140425; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem