The chemical industry reduces the impact on the environment during synthesis 934-22-5, name is 6-Aminobenzimidazole, I believe this compound will play a more active role in future production and life. 934-22-5
2,3-Dibromo-5-ethoxy-6-hydroxybenzaldehyde (0.1 g, 0.31 mmol), 5-Aminobenzimidazole (0.03 g, 0.20 mmol), and isoamyl alcohol (2 mL) were stirred at room temperature under N2. Acetic acid (0.07 mL) was added drop-wise, and the mixture was refluxed overnight. The reaction mixture was filtered, washed with CH2Cl2, MeOH, and dried to yield 29 (0.06 g, 0.13 mmol, 65.4%) as an orange powder. 1H NMR (DMSO, 300 MHz) delta 15.57 (s, 1H), 12.50 (bs, 1H), 9.20 (s, 1H), 8.31 (s, 1H), 7.81-7.68 (m, 2H), 7.38 (s, 1H), 7.35 (s, 1H), 4.10 (q, 2H, J=6.9 Hz), 1.36 (t, 3H, J=6.9 Hz); 13C NMR (DMSO, 700 MHz) delta 162.36, 154.82, 148.63, 144.23, 140.92, 120.40, 119.77, 117.69, 117.42, 117.30, 116.15, 113.00, 111.88, 104.91, 65.01, 15.00. Rf=0.48 (CH2Cl2/MeOH 9:1)
The chemical industry reduces the impact on the environment during synthesis 934-22-5. I believe this compound will play a more active role in future production and life.
Reference:
Article; Shim, Hyun Jae; Yang, Hye Ran; Kim, Han Ie; Kang, Shin-Ae; No, Kyoung Tai; Jung, Young Hoon; Lee, Seung-Taek; Bioorganic and Medicinal Chemistry Letters; vol. 24; 19; (2014); p. 4659 – 4663;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem