312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 312-73-2
The 2 – trifluoromethyl – 1H – benzimidazole 2 (1.35g, 10mmol) added to the is provided with a 15 ml round bottom flask in acetone, stirring to dissolve into the ene (alkyne) propyl bromide (0.87 ml, 10mmol) and K2CO3(2.07g, 15mmol), heating to reflux, TCL detection, after the reaction is complete, cooling, filtering to remove the solid, dichloromethane is used for washing the solid, acetone solution concentration after mixing with the dichloromethane solution, H for2O washing (15 ml ¡Á 3), organic phase with anhydrous MgSO4Drying, filtering the concentrated to obtain the crude product. To obtain 1 – allyl -2 – trifluoromethyl – 1H – benzimidazole (3) 2.10g, yield 94.34%.aceo
Statistics shows that 312-73-2 is playing an increasingly important role. we look forward to future research findings about 2-(Trifluoromethyl)-1H-benzo[d]imidazole.
Reference:
Patent; Zhejiang University of Technology; Zhu, Bingchun; Wang, Yuguang; Dong, Huichan; (15 pag.)CN104496976; (2017); B;,
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