71759-87-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, A new synthetic method of this compound is introduced below.
[0395] Under inert atmosphere, a mixture of Example 43f (100 mg, 0.27 mmol), Example 43g (144 mg, 0.69 mmol), Pd(PPh3)2Cl2 (19 mg, 0.027 mmol), triethylamine (272 mg, 2.7 mmol) and Cul (5.2 mg, 0.027 mmol) in 10 mL of DMF was stirred at 80C for 2 hours. The mixture was filtered and the filtrate was concentrated. The residue was purified by Prep-HPLC (by Ultimate XB-C18, 50 x 250 mm, 10 mum,, speed: 80 mL/min, eluent: H20/CH3CN = from 80/20 to 20/80 over 50 min)to give the desired product (17 mg, yield: 14.2%) as a yellow solid. LCMS [M+l] +=444.0 [0396] 1H NMR (400 MHz, DMSO-d6) delta 10.85 (s, 1H), 8.85 (s, 1H), 8.19 (d, J= 8.3 Hz, 1H), 8.02 (t, J= 8.0 Hz, 1H), 7.89 (d, J= 7.6 Hz, 1H), 7.77 (d, J= 7.1Hz, 1H), 7.68 (s, 1H), 7.57 (s, 1H), 7.38 (d, J=11.1Hz, 1H), 5.72 – 5.61 (m, 1H), 3.67 (s, 3H), 3.32 (s, 3H), 1.42 (d, J= 6.6 Hz, 6H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (227 pag.)WO2018/151830; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem