10111-08-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10111-08-7 as follows.
General procedure: A typical procedure involves, in a round-bottom flask equipped with a refluxcondenser, in which a mixture of 4-hydroxycoumarin (2 mmol), arylaldehyde(1 mmol), PIL catalyst (10 mol%) and 5 mL of ethanol was stirred at 80 C.The reaction was monitored by TLC. After completion of the reaction, a solidproduct is obtained which is filtered and recrystallized with ethanol(Scheme 2).
According to the analysis of related databases, Imidazole-2-carboxaldehyde, the application of this compound in the production field has become more and more popular.
Reference:
Article; Patil, Sandip K.; Awale, Deepak V.; Vadiyar, Madagonda M.; Patil, Suryakant A.; Bhise, Sagar C.; Kolekar, Sanjay S.; Research on Chemical Intermediates; vol. 43; 10; (2017); p. 5365 – 5376;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem