As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60-56-0 name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 60-56-0
3-methoxy salicylaldehyde 5 (1 mmol), malononitrile 6 (2.2 mmol), 2-mercaptoimidazole 7 (1.2 mmol), compound4 (20 mol%) and ethanol (5 mL) were sequentially added to a 50 mL round bottom flask, and fully reacted to completion at 80 C (TLC tracking supervision) Measurement). After cooling to room temperature, suction filtration, the product was washed with a small amount of water, dissolved in N,N-dimethylformamide, filtered, and evaporated. The distilled water was precipitated as a solid, suction filtered, and recrystallized (DMSO) to give compound 8j in a yield of 80%. The structural formula of compound 8j is:The formula is: C18H15N6OSChinese name: 2,4-diamino-9-methyl-5-(1-methyl-1H-imidazol-2-ylthio)-5H-chromene[2,3-b]pyridine-3-carbonitrileThe English name is: 2,4-diamino-9-methyl-5-(1-methyl-1H-imidazol-2-ylthio)-5H-Chromeno[2,3-b]pyridine-3-carbonitrile
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-2(3H)-thione, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Normal University; Wu Hui; Yuan Rui; Ren Xuanxuan; Fang Yue; Chen Wen; Zhou Shengliang; Zhang Peng; Wan Yu; (15 pag.)CN108610348; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem